X0609 4 2026-07-27 0 0001649094 Vaxcyte, Inc. PCVX 0001258693 PICKERING GRANT false C/O VAXCYTE, INC. 825 INDUSTRIAL ROAD, STE. 300 SAN CARLOS CA 94070 1 1 0 0 CHIEF EXECUTIVE OFFICER 1 Common Stock 2026-07-27 4 M 0 16198 2.03 A 469445 D Common Stock 2026-07-27 4 S 0 11783 55.515 D 457662 D Common Stock 2026-07-27 4 S 0 4415 55.931 D 453247 D Common Stock 2026-07-27 4 S 0 756 55.516 D 133459 I By Children's Trust Common Stock 2026-07-27 4 S 0 244 55.964 D 133215 I By Children's Trust Common Stock 2026-07-27 4 S 0 622 55.54 D 133593 I By Children's Trust Common Stock 2026-07-27 4 S 0 378 55.914 D 133215 I By Children's Trust Stock Option (right to buy) 2.03 2026-07-27 4 M 0 16198 0 D 2028-07-24 Common Stock 16198 137000 D Includes 781 shares acquired under the Issuer's Employee Stock Purchase Plan on May 15, 2026. The sale reported on this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted March 3, 2026. The price reported is a weighted-average price. The shares were sold at prices ranging from $54.77 to $55.765. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. The price reported is a weighted-average price. The shares were sold at prices ranging from $55.77 to $56.13. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. The price reported is a weighted-average price. The shares were sold at prices ranging from $54.77 to $55.71. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. Shares are held directly by a trust for the benefit of the Reporting Person's son. The price reported is a weighted-average price. The shares were sold at prices ranging from $55.81 to $56.18. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. Shares are held directly by a trust for the benefit of the Reporting Person's daughter. The price reported is a weighted-average price. The shares were sold at prices ranging from $55.82 to $56.085. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. Option is fully vested and exercisable. Grant Pickering, by /s/ Peter N. Efremenko, Attorney-In-Fact 2026-07-28