X0609 4 2026-06-26 0 0001649094 Vaxcyte, Inc. PCVX 0001258693 PICKERING GRANT false C/O VAXCYTE, INC. 825 INDUSTRIAL ROAD, STE. 300 SAN CARLOS CA 94070 1 1 0 0 CHIEF EXECUTIVE OFFICER 1 Common Stock 2026-06-26 4 S 0 6683 54.275 D 468020 D Common Stock 2026-06-26 4 S 0 9137 55.265 D 458883 D Common Stock 2026-06-26 4 S 0 6417 56.121 D 452466 D Common Stock 2026-06-26 4 S 0 312 54.345 D 134903 I By Children's Trust Common Stock 2026-06-26 4 S 0 356 55.226 D 134547 I By Children's Trust Common Stock 2026-06-26 4 S 0 332 55.993 D 134215 I By Children's Trust Common Stock 2026-06-26 4 S 0 207 54.222 D 135008 I By Children's Trust Common Stock 2026-06-26 4 S 0 602 55.297 D 134406 I By Children's Trust Common Stock 2026-06-26 4 S 0 191 56.266 D 134215 I By Children's Trust The sale reported on this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted March 3, 2026. The price reported is a weighted-average price. The shares were sold at prices ranging from $53.755 to $54.75. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. The price reported is a weighted-average price. The shares were sold at prices ranging from $54.755 to $55.73. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. The price reported is a weighted-average price. The shares were sold at prices ranging from $55.815 to $56.60. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. The price reported is a weighted-average price. The shares were sold at prices ranging from $53.77 to $54.75. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. Shares are held directly by a trust for the benefit of the Reporting Person's son. The price reported is a weighted-average price. The shares were sold at prices ranging from $54.80 to $55.51. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. The price reported is a weighted-average price. The shares were sold at prices ranging from $55.88 to $56.12. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. The price reported is a weighted-average price. The shares were sold at prices ranging from $53.77 to $54.42. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. Shares are held directly by a trust for the benefit of the Reporting Person's daughter. The price reported is a weighted-average price. The shares were sold at prices ranging from $54.80 to $55.72. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. The price reported is a weighted-average price. The shares were sold at prices ranging from $56.00 to $56.54. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. Grant Pickering, by /s/ Peter N. Efremenko, Attorney-In-Fact 2026-06-26