X0609 4 2026-08-18 0001581280 Twist Bioscience Corp TWST 0001755970 Finn Patrick John false C/O TWIST BIOSCIENCE CORPORATION 681 GATEWAY BLVD. SOUTH SAN FRANCISCO CA 94080 false true false false President and COO 1 Common Stock 2026-08-18 4 M false 23355 67.85 A 293033 D Common Stock 2026-08-18 4 S false 33354 115.899 D 259679 D Common Stock 2026-08-18 4 S false 10420 116.8202 D 249259 D Common Stock 2026-08-18 4 S false 8868 117.697 D 240391 D Common Stock 2026-08-18 4 S false 4500 119.040 D 235891 D Common Stock 2026-08-18 4 S false 12917 119.858 D 222974 D Common Stock 2026-08-18 4 S false 6296 121.007 D 216678 D Common Stock 2026-08-18 4 S false 2000 122.581 D 214678 D Stock Option (right to buy) 67.85 2026-08-18 4 M false 23355 0 D 2030-08-31 Common Stock 23355 0 D The transactions reported on this Form 4 were affected pursuant to a Rule 10b5-1 trading plan previously adopted by the Reporting Person on May 18, 2026. Represents the weighted average sales price per share. The shares sold at prices ranging from $115.35 to $116.33 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer. Represents the weighted average sales price per share. The shares sold at prices ranging from $116.37 to $117.36 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer. Represents the weighted average sales price per share. The shares sold at prices ranging from $117.37to $118.19 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer. Represents the weighted average sales price per share. The shares sold at prices ranging from $118.505 to $119.45 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer. Represents the weighted average sales price per share. The shares sold at prices ranging from $119.515 to $120.2 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer. Represents the weighted average sales price per share. The shares sold at prices ranging from $120.585 to $121.53 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer. Represents the weighted average sales price per share. The shares sold at prices ranging from $122.00 to $122.815 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer. The option was 100% exercisable on December 19, 2022. /s/ Kendra Fox, as Attorney-in-Fact for Patrick John Finn 2026-08-20