<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0508</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2026-01-02</periodOfReport>

    <issuer>
        <issuerCik>0001075531</issuerCik>
        <issuerName>Booking Holdings Inc.</issuerName>
        <issuerTradingSymbol>BKNG</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001214607</rptOwnerCik>
            <rptOwnerName>MYLOD ROBERT J JR</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>BOOKING HOLDINGS INC.</rptOwnerStreet1>
            <rptOwnerStreet2>800 CONNECTICUT AVENUE</rptOwnerStreet2>
            <rptOwnerCity>NORWALK</rptOwnerCity>
            <rptOwnerState>CT</rptOwnerState>
            <rptOwnerZipCode>06854</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>false</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>1</aff10b5One>

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                <value>Common Stock</value>
                <footnoteId id="F1"/>
            </securityTitle>
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            </transactionDate>
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                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>1</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>5253.595</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
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                    <value>919</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Annox Capital, LLC</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
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                <transactionPricePerShare>
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                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
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                <sharesOwnedFollowingTransaction>
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                <footnoteId id="F1"/>
            </securityTitle>
            <transactionDate>
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            </transactionDate>
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                <transactionFormType>4</transactionFormType>
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            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>2</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>5278.46</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
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                <sharesOwnedFollowingTransaction>
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                </sharesOwnedFollowingTransaction>
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            <ownershipNature>
                <directOrIndirectOwnership>
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                </directOrIndirectOwnership>
                <natureOfOwnership>
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                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
                <footnoteId id="F1"/>
            </securityTitle>
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            </transactionDate>
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            <transactionAmounts>
                <transactionShares>
                    <value>3</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>5284.28</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
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                </transactionAcquiredDisposedCode>
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                <sharesOwnedFollowingTransaction>
                    <value>907</value>
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                <transactionPricePerShare>
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                </transactionShares>
                <transactionPricePerShare>
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                <sharesOwnedFollowingTransaction>
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            </transactionDate>
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            <securityTitle>
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                    <value>5293.17</value>
                </transactionPricePerShare>
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                <sharesOwnedFollowingTransaction>
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                <directOrIndirectOwnership>
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                    <footnoteId id="F2"/>
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            <securityTitle>
                <value>Common Stock</value>
                <footnoteId id="F1"/>
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            </transactionDate>
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                <transactionFormType>4</transactionFormType>
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                <transactionShares>
                    <value>3</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>5293.98</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
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                <sharesOwnedFollowingTransaction>
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                <directOrIndirectOwnership>
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            <securityTitle>
                <value>Common Stock</value>
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                <transactionShares>
                    <value>4</value>
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                <transactionPricePerShare>
                    <value>5308.69</value>
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                <transactionAcquiredDisposedCode>
                    <value>D</value>
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                <directOrIndirectOwnership>
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            <securityTitle>
                <value>Common Stock</value>
                <footnoteId id="F1"/>
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                <transactionFormType>4</transactionFormType>
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            <transactionAmounts>
                <transactionShares>
                    <value>2</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>5313.63</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
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                <sharesOwnedFollowingTransaction>
                    <value>882</value>
                </sharesOwnedFollowingTransaction>
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            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
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                    <footnoteId id="F2"/>
                </natureOfOwnership>
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            <securityTitle>
                <value>Common Stock</value>
                <footnoteId id="F1"/>
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                    <value>5356</value>
                </transactionPricePerShare>
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                    <value>D</value>
                </transactionAcquiredDisposedCode>
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                <sharesOwnedFollowingTransaction>
                    <value>880</value>
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            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Annox Capital, LLC</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
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        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>2693</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value></value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">The 10b5-1(c) sales plan was adopted on August 7, 2025.</footnote>
        <footnote id="F2">The reporting person is the managing member of Annox Capital, LLC and as a result may be deemed to beneficially own the securities held of record by Annox Capital, LLC.  The reporting person disclaims such beneficial ownership except to the extent of his pecuniary interest therein, if any.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Vijay Iyer, Attorney-in-Fact</signatureName>
        <signatureDate>2026-01-05</signatureDate>
    </ownerSignature>
</ownershipDocument>
