X0609 4 2026-06-16 0 0001937993 Cadrenal Therapeutics, Inc. CVKD 0001405290 Pham Quang X false C/O CADRENAL THERAPEUTICS, INC. 822 A1A NORTH, SUITE 306 PONTE VEDRA FL 32082 1 1 1 0 Chairman, CEO and Interim CFO 1 Common Stock 2026-06-16 4 S 0 3613 3.18 D 129102 D Common Stock 2026-06-17 4 S 0 513 3.16 D 128589 D Common Stock 200000 I The PVBQ Living Trust Represents shares of the Issuer's common stock sold by the Reporting Person in accordance with a Rule 10b5-1 trading arrangement adopted by the Reporting Person on September 25, 2025. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.04 through $3.37. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the Staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.14 through $3.20. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the Staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Quang Pham is the Trustee of The PVBQ Living Trust and has sole voting and dispositive power with respect to the shares owned by The PVBQ Trust, of which Mr. Pham's child is the sole beneficiary. /s/ Quang X. Pham 2026-06-18