X0609 4 2026-03-26 0001356090 PRECIGEN, INC. PGEN 0001091823 KIRK RANDAL J false C/O THIRD SECURITY, LLC 1881 GROVE AVENUE RADFORD VA 24141 true false true false 0 Common Stock 2026-03-30 4 S false 1108998 3.30 D 80672818 I by R.J. Kirk DOT Common Stock 2026-03-30 4 S false 50797 3.30 D 426695 I by JPK 2008 Common Stock 2026-03-30 4 S false 370847 3.30 D 3238210 I by JPK 2009 Common Stock 2026-03-30 4 S false 152063 3.30 D 1463571 I by JPK 2012 Common Stock 2026-03-30 4 S false 50797 3.30 D 425732 I by MGK 2008 Common Stock 2026-03-30 4 S false 426199 3.30 D 3358917 I by MGK 2009 Common Stock 2026-03-30 4 S false 168794 3.30 D 1425544 I by MGK 2011 Common Stock 2026-03-30 4 S false 47101 3.30 D 519061 I by ZSK 2008 Common Stock 2026-03-30 4 S false 38976 3.30 D 302213 I by ZSK 2009 Common Stock 2026-03-30 4 S false 23789 3.30 D 423984 I by Kellie L. Banks LTT Common Stock 2026-03-30 4 S false 2334420 3.30 D 12262741 I by Sunset 2020 Common Stock 4598044 I by Kapital Joe Common Stock 1403 I by Lotus Common Stock 6085471 I by Third Security Common Stock 1096686 I by Parkview 2020 The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.22 to $3.58, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (1) to this Form 4. Randal J. Kirk controls each of R.J. Kirk Declaration of Trust ("R.J. Kirk DOT"), JPK 2008 LLC ("JPK 2008"), JPK 2009 LLC ("JPK 2009"), JPK 2012 LLC ("JPK 2012"), MGK 2008 LLC ("MGK 2008"), MGK 2009 LLC ("MGK 2009"), MGK 2011 LLC ("MGK 2011"), ZSK 2008 LLC ("ZSK 2008"), ZSK 2009 LLC ("ZSK 2009"), Kellie L. Banks (2009) Long Term Trust ("Kellie L. Banks LTT"), Sunset 2020, LLC ("Sunset 2020"), Kapital Joe, LLC ("Kapital Joe"), Lotus Capital (2000) Company, Inc. ("Lotus"), Third Security, LLC ("Third Security") and Parkview 2020 Limited Partnership ("Parkview 2020"). Shares held by these entities may be deemed to be beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein. /s/ Randal J. Kirk 2026-03-31