X0508 4 2026-03-03 0 0001232524 Jazz Pharmaceuticals plc JAZZ 0001193210 COZADD BRUCE C 5TH FL, WATERLOO EXCHANGE WATERLOO RD DUBLIN 4 L2 IRELAND 1 0 0 0 1 Ordinary Shares 2026-03-03 4 S 0 3159 186.0853 D 408637 D Ordinary Shares 2026-03-03 4 S 0 2608 186.734 D 406029 D Ordinary Shares 2026-03-03 4 S 0 233 187.8444 D 405796 D This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $185.500 to $186.4207. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected. Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $186.500 to $187.4693. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected. Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $187.7783 to $188.1678 The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected. By: /s/Paz Dizon, as attorney in fact For: Bruce C. Cozadd 2026-03-04