X0609 4 2026-10-06 0001674416 CRISPR Therapeutics AG CRSP 0001708172 KASINGER JAMES R. false C/O CRISPR THERAPEUTICS 105 WEST FIRST STREET BOSTON MA 02127 false true false false General Counsel and Secretary true Common Shares 2026-10-06 4 M false 1990 13.62 A 96774 D Common Shares 2026-10-06 4 S false 1990 60.0408 D 94784 D Stock Option (Right to Buy) 13.62 2026-10-06 4 M false 1990 0.00 D 2027-05-31 Common Shares 1990 81242 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 6, 2026. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $60.00 to $60.08, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. This option was granted on May 31, 2017 with respect to 123,000 Common Shares of which 25% shall vest on May 31, 2018 and the remaining 75% shall vest monthly thereafter for 36 months. /s/ Elizabeth Ryland Waldinger, attorney-in-fact 2026-10-08