X0609 4 2026-10-07 0001812364 Relay Therapeutics, Inc. RLAY 0001816210 Patel Sanjiv false C/O RELAY THERAPEUTICS, INC. 60 HAMPSHIRE STREET CAMBRIDGE MA 02139 true true false false President and CEO true Common Stock 2026-10-07 4 S false 48199 18.10 D 471301 D Common Stock 199548 I By The Patel Family Irrevocable Trust of 2019 Common Stock 687355 I By The SSP Irrevocable Trust of 2020 The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 30, 2025. This transaction was executed in multiple trades at prices ranging from $17.87 to $18.46. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request by the staff of the Securities and Exchange Commission, the Issuer or a security holder of the Issuer, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. These shares are held in irrevocable trusts for the benefit of the reporting person's family members. An independent trustee is trustee of the trusts. The reporting person disclaims beneficial ownership of these securities, and the filing of this report is not an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose. /s/ Soo-Yeun Lim, as attorney-in-fact 2026-10-08