X0609 4 2026-10-05 0001631574 Wave Life Sciences, Inc. WVE 0001572315 Verdine Gregory L. false C/O WAVE LIFE SCIENCES, INC., 733 CONCORD AVE. CAMBRIDGE MA 02138 true false false false false Common Stock 2026-10-05 4 A false 10700 0 A 200917 D Common Stock 75000 I See Footnote Stock Option (right to buy) 3.75 2026-10-05 4 A false 64000 0.00 A 2036-10-05 Common Stock 64000 64000 D The reporting person was granted this restricted stock unit award (RSU) pursuant to the 2026 Non-Employee Director Compensation Policy. The RSU vests as to 100% of the shares on the earlier of the Company's 2027 annual meeting of stockholders or October 5, 2027. Consists of shares of common stock held in a trust by Lynet Holdings LLC. The reporting person is the sole manager of Lynet Holdings LLC and the settlor of the trust and may be deemed to have shared voting and investment power over the shares. The reporting person disclaims beneficial ownership of the shares held except to the extent of his pecuniary interest therein. The reporting person was granted this option pursuant to the 2026 Non-Employee Director Compensation Policy. The option vests as to 100% of the shares on the earlier of the Company's 2027 annual meeting of stockholders or October 5, 2027. On August 7, 2026, Wave Life Sciences, Inc., a Delaware corporation, became the successor of Wave Life Sciences Ltd., a company organized under the laws of the Republic of Singapore ("Wave-Singapore"), pursuant to a scheme of arrangement under Singapore law under which all issued ordinary shares in the capital of Wave-Singapore were exchanged on a one-for-one basis for shares of common stock of Wave Life Sciences, Inc. (the "Redomiciliation"). The Redomiciliation had the effect of changing Wave-Singapore's domicile, but did not alter the proportionate interests of securityholders. Exhibit 24.1 - Power of Attorney /s/ Gregory L. Verdine 2026-10-07