X0609 4 2026-10-01 0001819133 Tango Therapeutics, Inc. TNGX 0001825445 Crystal Adam false C/O TANGO THERAPEUTICS, INC. 201 BROOKLINE AVE., SUITE 901 BOSTON MA 02215 false true false false President, R&D true Common Stock 2026-10-01 4 M false 27000 5.2 A 142743 D Common Stock 2026-10-01 4 S false 26400 24.4547 D 116343 D Common Stock 2026-10-01 4 S false 600 25.32 D 115743 D Stock Option (Right to Buy) 5.2 2026-10-01 4 M false 27000 0 D 2033-03-01 Common Stock 27000 233040 D These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on October 27, 2025. Represents the weighted average sales price per share. The shares sold at prices ranging from $23.96 to $24.95 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer. Represents the weighted average sales price per share. The shares sold at prices ranging from $25.04 to $25.41 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer. This option shall vest and become exercisable over a four-year period, at a rate of 25% on February 27, 2024, with the remaining option shares vesting in 36 equal monthly installments thereafter. /s/ Julie Fogarty, as attorney-in-fact 2026-10-05