X0609 4 2026-09-22 0001819133 Tango Therapeutics, Inc. TNGX 0002130408 Newcomb Jessica false C/O TANGO THERAPEUTICS, INC. 201 BROOKLINE AVE., SUITE 901 BOSTON MA 02215 false true false false Principal Accounting Officer true Common Stock 2026-09-22 4 S false 700 22.8029 D 66621 D Common Stock 2026-09-22 4 S false 5100 23.9683 D 61521 D Common Stock 2026-09-22 4 S false 2400 25.1718 D 59121 D These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on June 23, 2026. Represents the weighted average sales price per share. The shares sold at prices ranging from $22.37 to $23.32 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer. The amount reported in Column 2 includes 43,666 unvested restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of Common Stock of the Issuer. Represents the weighted average sales price per share. The shares sold at prices ranging from $23.52 to $24.41 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer. Represents the weighted average sales price per share. The shares sold at prices ranging from $24.59 to $25.56 per share. Full information regarding the number of shares sold at each price shall be provided upon request to the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer. /s/ Julie Fogarty, as attorney-in-fact 2026-09-24