X0609 4 2026-09-08 0001785279 Metagenomi Therapeutics, Inc. MGX 0001995697 Irish Jian false C/O METAGENOMI THERAPEUTICS, INC. 5959 HORTON STREET, 7TH FLOOR EMERYVILLE CA 94608 true true false false See Remarks false Common Stock 2026-09-08 4 S false 2140 1.1584 D 375393 D Common Stock 292714 I By Trust Common stock 292713 I By Trust These shares of common stock were automatically sold for the purpose of satisfying the Reporting Person's tax withholding obligations upon the vesting of certain restricted stock units granted to the Reporting Person on April 1, 2024 and April 1, 2025, and does not represent a volitional trade by the Reporting Person. Shares held by the Bruce Irish 2023 Irrevocable Trust FBO Jian Irish. The Reporting Person disclaims beneficial ownership of these securities except to the extent of her pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose. Shares held by the Jian Irish 2023 Irrevocable Trust. The Reporting Person disclaims beneficial ownership of these securities except to the extent of her pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose. President and Chief Executive Officer /s/ Matthew L. Wein, attorney-in-fact 2026-09-10