X0609 4 2026-09-04 false 0001782223 Pyxis Oncology, Inc. PYXS 0001723092 Civik Thomas false C/O PYXIS ONCOLOGY, INC. 321 HARRISON AVENUE, 11TH FL. SUITE 1 BOSTON MA 02118 true true false false CEO & Chairman of the Board false Stock Option (Right to Buy) 3.89 2026-09-04 4 A false 2503050 0 A 2036-09-04 Common Stock 2503050 2503050 D The shares subject to this option will vest over four years, with 25% vesting on the first anniversary of September 4, 2026 and the remainder vesting in 36 equal monthly installments thereafter, subject to the reporting person's continued employment through the applicable vesting date. /s/ Jitendra Wadhane, Attorney-in-Fact for Thomas Civik 2026-09-08