X0609 4 2026-08-24 0001816736 Disc Medicine, Inc. IRON 0001951849 Yu Jonathan Yen-Wen false C/O DISC MEDICINE, INC. 321 ARSENAL STREET, SUITE 101 WATERTOWN MA 02472 false true false false Chief Operating Officer true Common Stock 2026-08-24 4 M false 300 13.50 A 54624 D Common Stock 2026-08-24 4 S false 300 82.5333 D 54324 D Common Stock 2026-08-25 4 M false 8796 13.50 A 63120 D Common Stock 2026-08-25 4 S false 8796 83.1164 D 54324 D Stock Option (Right to Buy) 13.50 2026-08-24 4 M false 300 0 D 2032-12-28 Common Stock 300 22643 D Stock Option (Right to Buy) 13.50 2026-08-25 4 M false 8796 0 D 2032-12-28 Common Stock 8796 13847 D These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 17, 2026. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $82.50 to $82.60, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnotes (2) and (3) to this Form 4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $82.57 to $83.47, inclusive. The shares underlying this option vest in 48 equal monthly installments following December 29, 2022, subject to the Reporting Person's continued service on each such vesting date. By: /s/ Rahul Khara, as Attorney-in-Fact 2026-08-26