<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0609</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2026-08-20</periodOfReport>

    <issuer>
        <issuerCik>0002132582</issuerCik>
        <issuerName>Lyntris Inc.</issuerName>
        <issuerTradingSymbol>LYNX</issuerTradingSymbol>
        <issuerForeignTradingSymbol></issuerForeignTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0002147719</rptOwnerCik>
            <rptOwnerName>Cope Tanner</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerNonUSAddressFlag>false</rptOwnerNonUSAddressFlag>
            <rptOwnerStreet1>C/O LYNTRIS INC.</rptOwnerStreet1>
            <rptOwnerStreet2>3130 FAIRVIEW PARK DRIVE, SUITE 230</rptOwnerStreet2>
            <rptOwnerCity>FALLS CHURCH</rptOwnerCity>
            <rptOwnerState>VA</rptOwnerState>
            <rptOwnerZipCode>22042</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>false</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>false</aff10b5One>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2026-08-20</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>J</transactionCode>
                <equitySwapInvolved>false</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>231987</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0.00</value>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>231987</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">As previously disclosed by the Issuer in its registration statement on Form S-1 (as amended and/or supplemented from time to time) filed in connection with the Issuer's initial public offering (the &quot;IPO&quot;), concurrently with the consummation of the IPO, certain entities affiliated with Trive Capital Holdings LLC effectuated a distribution-in-kind (the &quot;Distribution in Kind&quot;) to its limited and general partners for no consideration, consisting of all shares of common stock of the Issuer (&quot;Common Stock&quot;) held by such entities that were not sold in the IPO. In the Distribution in Kind, the Reporting Person received 231,987 shares of Common Stock for no consideration.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Tim Paulin, Attorney-in-Fact</signatureName>
        <signatureDate>2026-08-21</signatureDate>
    </ownerSignature>
</ownershipDocument>
