X0609 4 2026-08-12 false 0001782223 Pyxis Oncology, Inc. PYXS 0001723092 Civik Thomas false C/O PYXIS ONCOLOGY, INC. 321 HARRISON AVENUE, 11TH FL. SUITE 1 BOSTON MA 02118 true true false false Interim CEO false Stock Option (Right to Buy) 1.49 2026-08-12 4 A false 250956 0 A 2026-08-12 2036-02-03 Common Stock 250956 941087 D Represents the performance-based portion of an option that was granted on February 3, 2026, which shares subject to this portion of the option were to become vested in full upon the completion of a successful financing transaction or a successful strategic transaction during the reporting person's continued service as Interim Chief Executive Officer or within six months thereafter. The performance conditions were deemed to have been met on August 12, 2026, as determined by the Board. /s/ Jitendra Wadhane, Attorney-in-Fact for Thomas Civik 2026-08-14