X0609 4 2026-08-07 0001637715 OnKure Therapeutics, Inc. OKUR 0001328625 Mathers Edward T false 104 5TH AVE 19TH FLOOR NEW YORK NY 10011 true false false false false Stock Option (right to buy) 4.14 2026-08-07 4 A false 22350 0 A 2036-08-06 Class A Common Stock 22350 22350 D 100% of the shares subject to the option will vest on the earlier of June 4, 2027 or the day prior to the date of the Issuer's next annual meeting of stockholders, subject to the Reporting Person continuing as a service provider through the applicable vesting date. /s/ Zachary Bambach, attorney-in-fact 2026-08-11