X0609 4 2026-04-09 0001620463 LeonaBio, Inc. LONA 0001224962 PERCEPTIVE ADVISORS LLC false 51 ASTOR PLACE, 10TH FLOOR NEW YORK NY 10003 true false true false 0001164426 EDELMAN JOSEPH false 51 ASTOR PL, 10TH FLOOR NEW YORK NY 10003 true false true false 0001249675 PERCEPTIVE LIFE SCIENCES MASTER FUND LTD false 51 ASTOR PLACE, 10TH FLOOR NEW YORK NY 10003 true false true false false Stock Option (Right to Buy) 9.54 2026-04-09 4 A false 28000 0 A 2036-04-08 Common Stock 28000 28000 I See footnote The shares subject to the option shall be scheduled to vest monthly over a term of 24 months on the monthly anniversaries of the grant date, subject to the optionee continuing to be a Service Provider (as defined in the Issuer's 2026 Equity Incentive Plan) through the applicable vesting dates. Joseph Edelman ("Mr. Edelman") is the managing member of Perceptive Advisors LLC (the "Advisor"). The Advisor serves as the investment manager of Perceptive Life Sciences Master Fund Ltd. (the "Master Fund"). The Advisor may be deemed to have an indirect pecuniary interest in the securities reported herein because the Advisor has the right to receive the director compensation provided in respect of Mr. Edelman's board service through a partial management fee offset. Each of the Master Fund and the Advisor disclaim, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of its indirect pecuniary interest therein, and this report shall not be deemed an admission that either the Master Fund or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purpose. /s/ Joseph Edelman - for Perceptive Advisors LLC, By: Joseph Edelman, its managing member 2026-07-10 /s/ Joseph Edelman - for Perceptive Life Sciences Master Fund Ltd., By: Perceptive Advisors LLC, its investment manager, By: Joseph Edelman, its managing member 2026-07-10 /s/ Joseph Edelman 2026-07-10