X0609 4 2026-06-10 0001572616 FRACTYL HEALTH, INC. GUTS 0001177319 BRADLEY WILLIAM false 3 VAN DE GRAAFF DRIVE SUITE 200 BURLINGTON MA 01803 true false false false false Common Stock 2026-06-10 4 P false 68493 0.7348 A 84622 D Stock Option 0.7318 2026-06-10 4 A false 22500 0 A 2036-06-09 Common Stock 22500 22500 D Open market purchase. The stock option was awarded as compensation for the Reporting Person's service on the Issuer's board of directors pursuant to the Issuer's non-employee director compensation policy. The stock option will vest and become exercisable in a single installment on the earlier of (i) the date of the next annual meeting of stockholders or (ii) the first anniversary of the grant, in each case subject to continued service on the Issuer's board of directors as a non-employee director through the vesting date. /s/ Harith Rajagopalan, M.D., Ph.D., Attorney-in-fact 2026-06-11