X0609 4 2026-06-03 0001563880 Trevi Therapeutics, Inc. TRVI 0001328625 Mathers Edward T false 104 5TH AVE 19TH FLOOR NEW YORK NY 10011 true false false false false Nonstatutory Stock Option (right to buy) 13.45 2026-06-03 4 A false 35000 0 A 2036-06-02 Common Stock 35000 35000 D This option was granted on June 3, 2026. This option is scheduled to fully vest on the earlier of (i) the first anniversary of the date of grant and (ii) the date of the next annual meeting of stockholders of the Issuer held following the date of grant, subject to the recipient's continued service as a director, employee or consultant of the Issuer. /s/ Zachary Bambach, attorney-in-fact 2026-06-04