X0609 4 2026-06-01 0001582313 Xenon Pharmaceuticals Inc. XENE 0001574579 Svoronos Dawn true 3650 GILMORE WAY BURNABY BRITISH COLUMBIA, CANADA A1 V5G 4W8 BRITISH COLUMBIA, CANADA true false false false false Common Shares 2026-06-01 4 M false 2645 A 27645 D Common Shares 2026-06-01 4 F false 1416 53.41 D 26229 D Restricted Share Units 2026-06-01 4 M false 2645 0 D Common Shares 2645 0 D Share Option (Right to Buy) 53.46 2026-06-03 4 A false 10507 0 A 2036-06-02 Common Shares 10507 10507 D Restricted Share Units 0 2026-06-03 4 A false 1593 0 A Common Shares 1593 1593 D Represents Common Shares earned and vested under a restricted share unit ("RSU") award granted to the reporting person on June 5, 2025. The RSU award vested 100% on June 1, 2026, the day before the date of the issuer's 2026 annual meeting of shareholders. Represents the number of Common Shares withheld by the issuer to satisfy income tax withholding and remittance obligations in connection with the net settlement of the RSUs, and does not represent a sale. Represents the closing price of Common Shares on June 1, 2026 for purposes of net settlement calculations. Vesting 100% on the earlier of (i) June 1, 2027 or (ii) the day before the date of the issuer's 2027 annual meeting of shareholders. Each RSU represents a contingent right to receive one Common Share vesting 100% on the earlier of (i) June 1, 2027 or (ii) the day before the date of the issuer's 2027 annual meeting of shareholders. /s/ Nathaniel Adams, Attorney-in-fact 2026-06-03