X0609 4 2026-05-05 0001863127 Tyra Biosciences, Inc. TYRA 0001711463 Harris Todd false C/O TYRA BIOSCIENCES, INC. 2656 STATE STREET CARLSBAD CA 92008 true true false false President and CEO false Common Stock 2026-05-05 4 A false 79000 0 A 1437631 D Stock Option (Right to Buy) 33.93 2026-05-05 4 A false 265000 0 A 2036-05-04 Common Stock 265000 265000 D Represents restricted stock units ("RSUs") granted on May 5, 2026. 1/4 of the total number of RSUs granted vest on each of the first four anniversaries of May 5, 2026, the vesting commencement date, subject to the Reporting Person's continuous service through each vesting date. Each RSU represents a contingent right to receive one share of common stock of the Issuer. Includes RSUs. 1/48th of the shares subject to the option vest monthly following May 5, 2026, the vesting commencement date, subject to the Reporting Person's continuous service to the Issuer through each vesting date. /s/ Ali D. Fawaz, Attorney-in-Fact 2026-05-07