X0508 4 2026-02-26 0001579428 Axsome Therapeutics, Inc. AXSM 0001658379 Coleman Mark C/O AXSOME THERAPEUTICS, INC. ONE WORLD TRADE CENTER, 29TH FLOOR NEW YORK NY 10007 true false false false true Common Stock 2026-02-26 4 S false 25000 161.11 D 47140 D Common Stock 403856 I See Footnote Represents the sale of underlying shares of previously exercised stock options. Such transaction was pursuant to a pre-approved 10b5-1 plan, which has now been completed. Represents the weighted average sale price of a series of open market transactions with sale prices ranging between $160.33 and $162.26. Such shares are held by an entity, of which the reporting person has voting and dispositive power, and therefore, the reporting person is deemed to be the indirect beneficial owner of such shares. /s/ Nick Pizzie, Attorney-in-Fact 2026-02-27