X0508 4 2026-02-25 0001124140 EXACT SCIENCES CORP EXAS 0001941313 Baranick Brian C/O EXACT SCIENCES CORP. 5505 ENDEAVOR LANE MADISON WI 53719 false true false false EVP, GM, Precision Oncology false Common Stock 103874 D Common Stock 795 I Held in 401(k) Plan Restricted Stock Units 2026-02-25 4 A false 28063 0 A Common Stock 28063 28063 D In addition to the shares of Common Stock reported on this Form 4, which total 104,669 shares, Mr. Baranick also holds, in the aggregate, an additional 28,063 restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vest in four equal annual installments beginning on February 25, 2027. /s/ Brian Baranick by Mark Busch, attorney-in-fact 2026-02-27