X0508 4 2026-02-18 0001674416 CRISPR Therapeutics AG CRSP 0001682019 Kulkarni Samarth C/O CRISPR THERAPEUTICS 105 WEST FIRST STREET BOSTON MA 02127 true true false false Chief Executive Officer false Common Shares 2026-02-18 4 M false 13250 A 233073 D Common Shares 2026-02-19 4 S false 6967 52.58 D 226106 D Restricted Stock Units 2026-02-18 4 M false 13250 D Common Shares 13250 0 D Each restricted stock unit represents a contingent right to receive one share of CRSP Common Shares. Reflects 85,622 shares previously transferred from the Kulkarni 2023 GRAT to the Reporting Person. Amount reported represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of these restricted stock units. This sale is mandated by the Company's RSU Settlement Policy to fund the tax withholding obligation and does not represent a discretionary trade by the reporting person. This restricted stock unit award was granted on February 18, 2022 with respect to 53,000 Common Shares, with (i) one quarter of the shares vesting on February 18, 2023, (ii) one quarter of the shares vesting on February 18, 2024, (iii) one quarter of the shares vesting on February 18, 2025, and (iv) one quarter of the shares vesting on February 18, 2026. /s/ Samarth Kulkarni 2026-02-20