X0508 4 2026-02-19 0001563880 Trevi Therapeutics, Inc. TRVI 0001965585 Simon Farrell C/O TREVI THERAPEUTICS, INC. 195 CHURCH STREET, 16TH FLOOR NEW HAVEN CT 06510 false true false false Chief Commercial Officer false Stock Option (right to buy) 10.56 2026-02-19 4 A false 160000 0 A 2036-02-18 Common Stock 160000 160000 D This option was granted on February 19, 2026. The 160,000 shares of common stock underlying the option are scheduled to vest in equal monthly installments through February 19, 2030, subject to the reporting person's continued service with the issuer. /s/ Christopher Galletta, attorney-in-fact 2026-02-20