X0508 4 2026-02-02 0001579428 Axsome Therapeutics, Inc. AXSM 0001219927 TABUTEAU HERRIOT C/O AXSOME THERAPEUTICS, INC. ONE WORLD TRADE CENTER, 29TH FLOOR NEW YORK NY 10007 true true true false Chief Executive Officer true Common Stock 2026-02-02 4 M false 32410 8.02 A 39639 D Common Stock 2026-02-02 4 S false 32410 185.60 D 7229 D Common Stock 7344500 I See Footnote Stock Option (Right to Buy) 185.60 2026-02-02 4 M false 32410 0.00 D 2017-05-27 2026-05-27 Common Stock 32410 0 D Necessary exercise of stock options set to expire due to attainment of the 10-year expiration date of such options. Such transaction was pursuant to a pre-approved 10b5-1 plan, which has now been completed. Represents the subsequent sale of the underlying shares of the aforementioned exercise of stock options. Represents the weighted average sale price of a series of open market transactions with sale prices ranging between $183.85 and $186.89. Such shares are held by an entity, of which the reporting person has voting and dispositive power, and therefore, the reporting person is deemed to be the indirect beneficial owner of such shares. /s/ Nick Pizzie, Attorney-in-Fact 2026-02-02