X0508 4 2026-01-27 0001812364 Relay Therapeutics, Inc. RLAY 0001959229 Rahmer Peter C/O RELAY THERAPEUTICS, INC. 60 HAMPSHIRE STREET CAMBRIDGE MA 02139 false true false false See remarks false Common Stock 2025-12-31 5 A false 994 2.99 A 338463 D Common Stock 2026-01-27 4 S false 11684 7.62 D 277964 D Common Stock 2026-01-28 4 S false 1354 8.45 D 276610 D The shares were acquired under the Relay Therapeutics, Inc. 2020 Employee Stock Purchase Plan ("ESPP") in a transaction that was exempt under both Rule 16b-3(d) and Rule 16b-3(c). The reporting person is voluntarily reporting this transaction. In accordance with the ESPP, these shares were purchased at a price equal to 85% of the closing price of the Issuer's common stock on July 1, 2025. Includes 108,919 shares underlying restricted stock units ("RSUs"). Sale of shares to cover the reporting person's income tax withholding obligations upon the vesting of 42,394 shares of RSUs on January 26, 2026. The reporting person had no discretion with respect to such sale, which was transacted in accordance with the Issuer's policies regarding the vesting of RSUs. Includes 17,710 shares underlying RSUs. Sale of shares to cover the reporting person's income tax withholding obligations upon the vesting of 5,506 shares of RSUs on January 27, 2026. The reporting person had no discretion with respect to such sale, which was transacted in accordance with the Issuer's policies regarding the vesting of RSUs. Includes 12,204 shares underlying RSUs. Chief Corporate Development Officer /s/ Soo-Yeun Lim, as Attorney-in-Fact 2026-01-29