X0508 4 2026-01-22 0001674416 CRISPR Therapeutics AG CRSP 0001968317 Prasad Raju C/O CRISPR THERAPEUTICS 105 WEST FIRST STREET BOSTON MA 02127 false true false false Chief Financial Officer true Common Shares 2026-01-22 4 M false 34972 45.15 A 41739 D Common Shares 2026-01-22 4 S false 34972 60.19 D 6767 D Stock Option (Right to Buy) 45.15 2026-01-22 4 M false 34972 0.00 D 2033-03-14 Common Shares 34972 41667 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 18, 2025. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $60.00 to $60.42, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. This option was granted on March 14, 2023 with respect to 100,000 Common Shares, with 25% of the shares vesting on March 14, 2024 and the remaining shares vesting on each monthly anniversary thereafter for a period of 36 months. /s/ Elizabeth Ryland Waldinger, attorney-in-fact 2026-01-26