X0508 4 2026-01-06 0001674416 CRISPR Therapeutics AG CRSP 0001968317 Prasad Raju C/O CRISPR THERAPEUTICS 105 WEST FIRST STREET BOSTON MA 02127 false true false false Chief Financial Officer true Common Shares 2026-01-06 4 M false 23361 45.15 A 30128 D Common Shares 2026-01-06 4 M false 6339 44.31 A 36467 D Common Shares 2026-01-06 4 S false 18933.00 60.1799 D 17534.00 D Common Shares 2026-01-06 4 S false 5004 60.0000 D 12530 D Common Shares 2026-01-06 4 S false 5763.00 60.2134 D 6767 D Stock Option (Right to Buy) 45.15 2026-01-06 4 M false 23361.00 0.00 D 2033-03-14 Common Shares 23361.00 76639.00 D Stock Option (Right to Buy) 44.31 2026-01-06 4 M false 6339.00 0.00 D 2033-10-13 Common Shares 6339.00 7493.00 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 18, 2025. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $60.0000 to $60.7300, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $60.0000 to $60.4800, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. This option was granted on March 14, 2023 with respect to 100,000 Common Shares, with 25% of the shares vesting on March 14, 2024 and the remaining shares vesting on each monthly anniversary thereafter for a period of 36 months. This option was granted on October 13, 2023 with respect to 13,832 Common Shares. 100% of the shares will vest in 48 equal monthly installments, with the first vesting date of November 13, 2023. /s/ Elizabeth Ryland Waldinger, attorney-in-fact 2026-01-08