X0508 4 2026-01-06 0001327273 Lyra Therapeutics, Inc. LYRA 0001810701 Palasis Maria C/O LYRA THERAPEUTICS, INC. 480 ARSENAL WAY WATERTOWN MA 02472 true true false false President & CEO true Common Stock 2026-01-06 4 S false 1702 3.364 D 1096733 D Shares were sold to cover taxes upon the vesting of restricted stock units ("RSUs") pursuant to a mandatory Rule 10b5-1 trading instruction in the award agreement adopted by the Reporting Person on January 1, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. /s/ Jason Cavalier, Attorney-in-Fact for Maria Palasis, Ph.D. 2026-01-08