X0508 4 2026-01-06 0001812364 Relay Therapeutics, Inc. RLAY 0001816210 Patel Sanjiv C/O RELAY THERAPEUTICS, INC. 60 HAMPSHIRE STREET CAMBRIDGE MA 02139 true true false false President and CEO false Common Stock 2025-12-31 5 A false 994 2.99 A 704209 D Common Stock 2026-01-06 4 S false 43168 7.82 D 661041 D Common Stock 199548 I By The Patel Family Irrevocable Trust of 2019 Common Stock 687355 I By The SSP Irrevocable Trust of 2020 The shares were acquired under the Relay Therapeutics, Inc. 2020 Employee Stock Purchase Plan ("ESPP") in a transaction that was exempt under both Rule 16b-3(d) and Rule 16b-3(c). The reporting person is voluntarily reporting this transaction. In accordance with the ESPP, these shares were purchased at a price equal to 85% of the closing price of the Issuer's common stock on July 1, 2025. Includes 136,854 shares underlying restricted stock units ("RSUs"). Sale of shares to cover the reporting person's income tax withholding obligations upon the vesting of 136,854 shares of RSUs on January 5, 2026. The reporting person had no discretion with respect to such sale, which was transacted in accordance with the Issuer's policies regarding the vesting of RSUs. These shares are held in irrevocable trusts for the benefit of the reporting person's family members. An independent trustee is trustee of the trusts. The reporting person disclaims beneficial ownership of these securities, and the filing of this report is not an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose. These shares were held in irrevocable trusts for the benefit of the reporting person's family members. An independent trustee is trustee of the trusts. The reporting person disclaims beneficial ownership of these securities, and the filing of this report is not an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose. /s/ Soo-Yeun Lim, as attorney-in-fact 2026-01-07