X0508 4 2026-01-02 0001816736 Disc Medicine, Inc. IRON 0001951850 Khara Rahul C/O DISC MEDICINE, INC. 321 ARSENAL STREET, SUITE 101 WATERTOWN MA 02472 false true false false Chief Legal Officer true Common Stock 2026-01-02 4 M false 6500 13.5 A 44293 D Common Stock 2026-01-02 4 S false 350 77.6712 D 43943 D Common Stock 2026-01-02 4 S false 4993 78.6239 D 38950 D Common Stock 2026-01-02 4 S false 1157 79.2720 D 37793 D Stock Option (Right to Buy) 13.5 2026-01-02 4 M false 6500 0 D 2032-12-28 Common Stock 6500 22270 D The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on September 23, 2025. Includes 210 shares purchased pursuant to the Disc Medicine, Inc. Amended and Restated 2021 Employee Stock Purchase Plan on July 31, 2025. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $77.09 to $78.07, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (3) through (5) to this Form 4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $78.09 to $79.07, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $79.10 to $79.49, inclusive. The shares underlying this option vest in 48 equal monthly installments following December 29, 2022, subject to the Reporting Person's continued service on each such vesting date. By: /s/ Rahul Khara 2026-01-05