X0508 4 2025-12-17 0001851194 Ventyx Biosciences, Inc. VTYX 0001874108 Nuss John C/O VENTYX BIOSCIENCES, INC. 12790 EL CAMINO REAL, SUITE 200 SAN DIEGO CA 92130 false true false false CHIEF SCIENTIFIC OFFICER false Common Stock 2025-12-17 4 M false 34930 0 A 502156 D Common Stock 2025-12-18 4 S false 12675 7.7191 D 489481 D Restricted Stock Units 2025-12-17 4 M false 34930 0 D Common Stock 34930 0 D Each restricted stock unit ("RSU") represents a contingent right to receive one share of Ventyx Biosciences, Inc. common stock. Represents a broker-assisted sale to satisfy the Reporting Person's tax withholding obligations in connection with the vesting of restricted stock units. Represents the weighted average share price of an aggregate total of 12,675 shares sold in the price range of $7.595 to $7.85. The reporting owner undertakes to provide upon request by the Commission staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price. Subject to the reporting person's continuing to be a Service Provider (as defined in the 2021 Equity Incentive Plan) through such applicable vesting date, twenty five percent (25%) of the RSUs subject to the award shall vest on the one (1) year anniversary of the Vesting Commencement Date, and twenty five percent (25%) of the RSUs subject to the award shall vest on each of the next three Vesting Commencement Date anniversaries thereafter. "Vesting Commencement Date" shall mean December 17, 2021. /s/ Austin Rutherford, as Attorney-in-Fact 2025-12-19