X0508 4 2025-12-16 0000873303 Sarepta Therapeutics, Inc. SRPT 0001836254 Estepan Ian Michael 215 FIRST STREET SUITE 415 CAMBRIDGE MA 02142 false true false false Chief Operating Officer false Common Stock 2025-12-16 4 S false 13187 22.31 D 193300 D Represents a sale of shares of common stock to generate cash for the payment of taxes due as a result of the vesting of certain restricted stock unit awards. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $22.35 to 22.29, inclusive. The reporting person undertakes to provide to the Company, any security holder of the Company, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above. /s/ Cristin L. Rothfuss, as Attorney-in-Fact for Ian Michael Estepan 2025-12-18