X0508 4 2025-12-15 0001816736 Disc Medicine, Inc. IRON 0001951852 Savage William Jacob C/O DISC MEDICINE, INC. 321 ARSENAL STREET, SUITE 101 WATERTOWN MA 02472 false true false false Chief Medical Officer true Common Stock 2025-12-15 4 S false 3642 90.6037 D 85153 D Common Stock 2025-12-15 4 S false 9151 91.4353 D 76002 D Common Stock 2025-12-15 4 S false 300 92.23 D 75702 D The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on June 26, 2025. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $90.02 to $90.97, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) and (3) to this Form 4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $91.03 to $91.99, inclusive. By: /s/ Rahul Khara, as Attorney-in-Fact 2025-12-16