X0508 4 2025-09-05 0001785279 Metagenomi, Inc. MGX 0002009713 Wein Matthew C/O METAGENOMI, INC. 5959 HORTON STREET, 7TH FLOOR EMERYVILLE CA 94608 false true false false See Remarks false Common Stock 2025-09-05 4 S false 199 1.81 D 19230 D Common Stock 2025-12-01 4 A false 96000 1.60 A 115230 D These shares of common stock were automatically sold for the purpose of satisfying the Reporting Person's tax withholding obligations upon the vesting of certain restricted stock units ("RSUs") granted to the Reporting Person on April 1, 2024, and does not represent a volitional trade by the Reporting Person. Includes 1,359 shares acquired under the Company's employee stock purchase plan ("ESPP") on May 30, 2025 and 1,377 shares acquired under the Company's ESPP on November 28, 2025. These shares represent RSUs. 50% of the RSUs shall vest on December 5, 2026, with the remainder vesting on December 5, 2027, subject to the Reporting Person's continued service with the Issuer on each such vesting date. Title: General Counsel, Compliance Officer and Corporate Secretary /s/ Matthew L. Wein 2025-12-01