X0508 4 2025-11-13 0001863127 Tyra Biosciences, Inc. TYRA 0001880946 Bensen Daniel C/O TYRA BIOSCIENCES, INC. 2656 STATE STREET CARLSBAD CA 92008 false true false false Chief Operating Officer true Common Stock 2025-11-13 4 S false 1111 16.0036 D 426870 D Common Stock 2025-11-14 4 S false 110228 16.0167 D 316642 D Common Stock 2025-11-17 4 S false 18572 16.1098 D 298070 D Common Stock 2025-11-17 4 S false 1500 17.0713 D 296570 D The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 5, 2024. Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $16.00 to $16.02. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request. Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $16.00 to $16.13. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request. Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $16.00 to $17.00. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request. Represents the weighted average sale price for the entire number of shares sold. The actual sale prices range between $17.06 to $17.09. Detailed information on the exact number of shares sold at each sale price can be obtained from the Issuer upon request. /s/ Ali D. Fawaz, Attorney-in-Fact 2025-11-17