X0508 4 2025-11-04 0001124140 EXACT SCIENCES CORP EXAS 0001957680 Herriott James C/O EXACT SCIENCES CORP. 5505 ENDEAVOR LANE MADISON WI 53719 false true false false SVP, General Counsel & Sec true Common Stock 2025-11-04 4 S false 1500 70.08 D 12585 D Common Stock 1556 I Held in 401(k) Plan The transaction reported in this field was effected pursuant to a Rule 10b5-1 trading plan entered into on March 3, 2025. In addition to the shares of Common Stock reported on this Form 4, which total 14,141 shares, Mr. Herriott also holds, in the aggregate, an additional 37,434 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. /s/ James Herriott by Mark Busch, attorney-in- fact 2025-11-06