X0508 4 2025-11-04 0001095981 PLUS THERAPEUTICS, INC. PSTV 0001802687 Sims Andrew John Hugh MacIntyre C/O PLUS THERAPEUTICS INC. 6420 LEVIT GREEN BOULEVARD, SUITE 310 HOUSTON TX 77021 false true false false Chief Financial Officer false Common Stock 2025-11-04 4 P false 20000 0.51 A 68138 D The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.504 to $0.509. The reporting person undertakes to provide the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote. /s/ Andrew Sims 2025-11-05