X0508 4 2025-10-27 0001861560 Nuvalent, Inc. NUVL 0001862123 Shair Matthew C/O NUVALENT, INC. ONE BROADWAY, 14TH FLOOR CAMBRIDGE MA 02142 true false false false true Class A Common Stock 2025-10-27 4 S false 14345 100.23 D 1415499 D Class A Common Stock 2025-10-27 4 S false 4046 100.23 D 212476 I See Footnote Class A Common Stock 2025-10-28 4 S false 32455 100.27 D 1383044 D Class A Common Stock 2025-10-28 4 S false 9154 100.27 D 203322 I See Footnote These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 20, 2024. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $100.00 to $100.88, inclusive. The reporting person undertakes to provide to the staff of the Securities and Exchange Commission, Nuvalent, Inc. or any security holder of Nuvalent, Inc., upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2) and (4) of this Form 4. These shares are held by Matthew D. Shair 2021 Irrevocable Family Trust. The reporting person has voting and dispositive power over the shares beneficially owned by Matthew D. Shair 2021 Irrevocable Family Trust. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $100.00 to $100.64, inclusive. /s/ Nathan McConarty, attorney-in-fact 2025-10-29