X0508 4 2025-10-20 0001861560 Nuvalent, Inc. NUVL 0001868741 Miller Deborah Ann C/O NUVALENT, INC. ONE BROADWAY, 14TH FLOOR CAMBRIDGE MA 02142 false true false false Chief Legal Officer true Class A Common Stock 2025-10-20 4 M false 5000 6.89 A 54086 D Class A Common Stock 2025-10-20 4 S false 5000 94.91 D 49086 D Stock Option (Right to Buy) 6.89 2025-10-20 4 M false 5000 0 D 2031-04-29 Class A Common Stock 5000 140608 D These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 18, 2024. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $94.80 to $95.00, inclusive. The reporting person undertakes to provide to the staff of the Securities and Exchange Commission, Nuvalent, Inc. or any security holder of Nuvalent, Inc., upon request, full information regarding the number of shares sold at each separate price. The shares underlying this option are fully vested. /s/ Nathan McConarty, attorney-in-fact 2025-10-22