X0508 4 2025-12-05 0 0001104506 INSMED Inc INSM 0001182633 SHAROKY MELVIN MD 700 US HIGHWAY 202/206 BRIDGEWATER NJ 08807 1 0 0 0 0 Common Stock 2025-12-05 4 S 0 20000 205.01 D 243948 D Common Stock 0 I By Baby Gator LLC Common Stock 5000 I By Padonia, LLC Common Stock 6847 I By spouse Common Stock 5180 I By Melvin Sharoky C/F Nolan M. Wink UTMA/FL Common Stock 3481 I By Melvin Sharoky C/F Tulia L. Sharoky UTMA/FL Common Stock 576 I By Melvin Sharoky C/F Adler J. Wink UTMA/FL Common Stock 4764 I By Melvin Sharoky C/F Sophie C. Wink UTMA/FL This is the weighted average sales price representing 20,000 shares sold at prices ranging from $205.00 to $205.09 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request. Reflects shares acquired in pro rata distributions of 23 and 1,250 shares from Baby Gator LLC and Padonia, LLC, respectively, each of which transactions were exempt from reporting pursuant to Rule 16a-9 and Rule 16a-13. Reflects a pro rata distribution of all of its shares to its members. Not a market sale. The Reporting Person is a managing member of Baby Gator LLC. Reflects a pro rata distribution of 5,000 shares to its members. Not a market sale. The Reporting Person is the managing member of Padonia, LLC. The Reporting Person is the custodian of Melvin Sharoky C/F Nolan M. Wink UTMA/FL. The Reporting Person is the custodian of Melvin Sharoky C/F Tulia L. Sharoky UTMA/FL. The Reporting Person is the custodian of Melvin Sharoky C/F Adler J. Wink UTMA/FL. The Reporting Person is the custodian of Melvin Sharoky C/F Sophie C. Wink UTMA/FL. /s/ Melvin Sharoky, M.D, by Michael A. Smith as Attorney-in-fact 2025-12-09