X0609 4 2026-10-02 0001178670 ALNYLAM PHARMACEUTICALS, INC. ALNY 0001511797 SUPRAN BRYAN false 675 WEST KENDALL STREET CAMBRIDGE MA 02142 1 EVP, CLO and Secretary 0 Common Stock 2026-10-02 4 S 0 1758 226.88 D 12807 D Represents shares automatically sold by the Company on behalf of the reporting person pursuant to a mandatory sell-to-cover provision in the award agreement required to cover minimum statutory tax withholding obligations that became due upon the vesting and settlement of restricted stock units. Brett Budzinski, Attorney-in-Fact For: Bryan Supran 2026-10-06