X0609 4 2026-09-22 0001717115 Tempus AI, Inc. TEM 0001114357 LEFKOFSKY ERIC P false C/O TEMPUS AI, INC. 600 WEST CHICAGO AVENUE, SUITE 510 CHICAGO IL 60654 true true true false CEO and Chairman 1 Class A Common Stock 2026-09-22 4 S 0 7394 76.57 D 8595389 I By Gray Media, LLC Class A Common Stock 2026-09-22 4 S 0 33770 77.29 D 8561619 I By Gray Media, LLC Class A Common Stock 2026-09-22 4 S 0 16152 78.23 D 8545467 I By Gray Media, LLC Class A Common Stock 2026-09-22 4 S 0 184 78.86 D 8545283 I By Gray Media, LLC Class A Common Stock 2026-09-22 4 S 0 17359 76.57 D 14968110 I By Blue Media, LLC Class A Common Stock 2026-09-22 4 S 0 79259 77.29 D 14888851 I By Blue Media, LLC Class A Common Stock 2026-09-22 4 S 0 37950 78.23 D 14850901 I By Blue Media, LLC Class A Common Stock 2026-09-22 4 S 0 432 78.86 D 14850469 I By Blue Media, LLC Class A Common Stock 2026-09-22 4 S 0 965 76.57 D 808666 I By Lefkofsky Family Foundation Class A Common Stock 2026-09-22 4 S 0 4420 77.29 D 804246 I By Lefkofsky Family Foundation Class A Common Stock 2026-09-22 4 S 0 2091 78.23 D 802155 I By Lefkofsky Family Foundation Class A Common Stock 2026-09-22 4 S 0 24 78.86 D 802131 I By Lefkofsky Family Foundation Class A Common Stock 2026-09-22 4 S 0 6431 76.57 D 143569 I By Vas.org Foundation Class A Common Stock 2026-09-22 4 S 0 29367 77.29 D 114202 I By Vas.org Foundation Class A Common Stock 2026-09-22 4 S 0 14042 78.23 D 100160 I By Vas.org Foundation Class A Common Stock 2026-09-22 4 S 0 160 78.86 D 100000 I By Vas.org Foundation Class A Common Stock 2098130 D Class A Common Stock 406 I By 346 Long LLC Class A Common Stock 5715203 I By Lefkofsky Family 2025 GRAT Class A Common Stock 206 I By Black Media, LLC Class A Common Stock 4284797 I By Lefkofsky Family 2026 GRAT This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 8, 2026. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $75.83 to $76.82 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The Reporting Person is (i) a member of, and controls a limited liability company that is a member of, 346 Long LLC, (ii) the sole manager of each of Black Media, LLC, Blue Media, LLC and Gray Media, LLC, (iii) a trustee of each of Lefkofsky Family Foundation and Vas.org Foundation. The Reporting Person's spouse is the trustee of the Lefkofsky Family 2025 GRAT and Lefkofsky Family 2026 GRAT. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $76.83 to $77.82 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $77.83 to $78.82 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $78.83 to $78.90 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. /s/ Andrew Polovin, Attorney-in-Fact 2026-09-24