X0609 4 2026-07-28 0001717115 Tempus AI, Inc. TEM 0001114357 LEFKOFSKY ERIC P false C/O TEMPUS AI, INC. 600 WEST CHICAGO AVENUE, SUITE 510 CHICAGO IL 60654 true true true false CEO and Chairman 1 Class A Common Stock 2026-07-28 4 S 0 20472 41.34 D 8754811 I By Gray Media, LLC Class A Common Stock 2026-07-28 4 S 0 30906 42.36 D 8723905 I By Gray Media, LLC Class A Common Stock 2026-07-28 4 S 0 6122 42.95 D 8717783 I By Gray Media, LLC Class A Common Stock 2026-07-28 4 S 0 48066 41.34 D 15342403 I By Blue Media, LLC Class A Common Stock 2026-07-28 4 S 0 72560 42.36 D 15269843 I By Blue Media, LLC Class A Common Stock 2026-07-28 4 S 0 14374 42.95 D 15255469 I By Blue Media, LLC Class A Common Stock 2026-07-28 4 S 0 2671 41.34 D 829460 I By Lefkofsky Family Foundation Class A Common Stock 2026-07-28 4 S 0 4031 42.36 D 825429 I By Lefkofsky Family Foundation Class A Common Stock 2026-07-28 4 S 0 798 42.95 D 824631 I By Lefkofsky Family Foundation Class A Common Stock 2026-07-28 4 S 0 17801 41.34 D 232199 I By Vas.org Foundation Class A Common Stock 2026-07-28 4 S 0 26875 42.36 D 205324 I By Vas.org Foundation Class A Common Stock 2026-07-28 4 S 0 5324 42.95 D 200000 I By Vas.org Foundation Class A Common Stock 2230721 D Class A Common Stock 406 I By 346 Long LLC Class A Common Stock 5715203 I By Lefkofsky Family 2025 GRAT Class A Common Stock 206 I By Black Media, LLC Class A Common Stock 4284797 I By Lefkofsky Family 2026 GRAT This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 8, 2026. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $40.79 to $41.78 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (4) and (5). The Reporting Person is (i) a member of, and controls a limited liability company that is a member of, 346 Long LLC, (ii) the sole manager of each of Black Media, LLC, Blue Media, LLC and Gray Media, LLC, (iii) a trustee of each of Lefkofsky Family Foundation and Vas.org Foundation. The Reporting Person's spouse is the trustee of the Lefkofsky Family 2025 GRAT and Lefkofsky Family 2026 GRAT. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $41.79 to $42.78 inclusive. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $42.79 to $43.13 inclusive. Represents the number of shares owned after Blue Media, LLC contributed a portion of its shares to the Lefkofsky Family 2026 GRAT. Represents the number of shares owned after the Lefkofsky Family 2025 GRAT distributed a portion of its shares to Blue Media, LLC. /s/ Andrew Polovin, Attorney-in-Fact 2026-07-30