X0609 4 2026-05-19 0001717115 Tempus AI, Inc. TEM 0001114357 LEFKOFSKY ERIC P false C/O TEMPUS AI, INC. 600 WEST CHICAGO AVENUE, SUITE 510 CHICAGO IL 60654 true true true false CEO and Chairman 0 Class A Common Stock 2026-05-19 4 S 0 22335 44.07 D 2230721 D Class A Common Stock 8841783 I By Gray Media, LLC Class A Common Stock 15656469 I By Blue Media, LLC Class A Common Stock 406 I By 346 Long LLC Class A Common Stock 10000000 I Lefkofsky Family 2025 GRAT Class A Common Stock 206 I By Black Media, LLC Class A Common Stock 832131 I By Lefkofsky Family Foundation Class A Common Stock 250000 I By Vas.org Foundation Represents the number of shares required to be sold to cover the statutory tax withholding obligations in connection with the vesting of the restricted stock units. This sale is mandated by the Issuer's election under its equity incentive plans to require the satisfaction of minimum statutory tax withholding obligations to be funded by a "sell to cover" transaction and does not represent a discretionary sale by the Reporting Person. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $43.65 to $44.46 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The Reporting Person is (i) a member of, and controls a limited liability company that is a member of, 346 Long LLC, (ii) the sole manager of each of Black Media, LLC, Blue Media, LLC and Gray Media, LLC, (iii) a trustee of each of Lefkofsky Family Foundation and Vas.org Foundation. The Reporting Person's spouse is the trustee of the Lefkofsky Family 2025 GRAT. /s/ Andrew Polovin, Attorney-in-Fact 2026-05-21