X0609 4 2026-09-11 0 0001583648 PALVELLA THERAPEUTICS, INC. PVLA 0001271081 JENKINS GEORGE M false C/O PALVELLA THERAPEUTICS, INC. 353 W. LANCASTER AVENUE, SUITE 200 WAYNE PA 19087 1 0 0 0 1 Common Stock 2026-09-11 4 S 0 6520 150.6189 D 181096 D Common Stock 2026-09-11 4 S 0 4577 151.7157 D 176519 D Common Stock 2026-09-11 4 S 0 1274 153.0591 D 175245 D Common Stock 2026-09-14 4 S 0 5632 151.4625 D 169613 D Common Stock 2026-09-14 4 S 0 6160 152.1159 D 163453 D Common Stock 2026-09-14 4 S 0 1560 153.099 D 161893 D Common Stock 2026-09-15 4 S 0 954 149.3779 D 160939 D Common Stock 2026-09-15 4 S 0 263 150.4045 D 160676 D Common Stock 2026-09-15 4 S 0 560 151.3263 D 160116 D Common Stock 13516 I By foundation The transactions reported by the Reporting Person were effected pursuant to a Rule 10b5-1 trading plan adopted on June 12, 2026. The plan was adopted during an open trading window, at a time when the Reporting Person was not in possession of material non-public information and was reviewed and approved in accordance with the Issuer's Insider Trading Policy. The Issuer's officers and directors from time to time utilize trading plans to transact in its securities for reasons such as satisfying vesting-related income tax requirements, investment diversification, or other personal reasons. Any profit required to be disgorged under Section 16 of the Securities Exchange Act of 1934, as amended, with respect to an aggregate of 445 shares sold in the transactions reported on this Form 4 will be disgorged to the Issuer pursuant to applicable requirements. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $150.23 to $151.18, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price at which the transactions were effected. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $151.23 to $152.09, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price at which the transactions were effected. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $152.42 to $153.30, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price at which the transactions were effected. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $150.80 to $151.785, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price at which the transactions were effected. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $151.80 to $152.70, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price at which the transactions were effected. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $152.88 to $153.34, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price at which the transactions were effected. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $148.90 to $149.50, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price at which the transactions were effected. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $150.0525 to $151.0225, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price at which the transactions were effected. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $151.16 to $151.65, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price at which the transactions were effected. Eagles Mere Air Museum Foundation. /s/ Kathleen A. McGowan, Attorney-in-Fact 2026-09-15