X0609 4 2026-08-26 0 0001814114 Orchestra BioMed Holdings, Inc. OBIO 0001723524 Sherman Darren false C/O ORCHESTRA BIOMED HOLDINGS, INC. 150 UNION SQUARE DRIVE NEW HOPE PA 18938 1 1 0 0 See Remarks 0 Common Stock, par value $0.0001 per share ("Common Stock") 2026-08-26 4 F 0 4925 5.26 D 1149402 D Common Stock 2026-08-26 4 P 0 2000 5.33 A 2000 I By son Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units ("RSUs"). No shares were sold in the market as a result of the vesting of these RSUs and the satisfaction of tax withholding obligations. The reporting person disclaims beneficial ownership of these securities, and this report shall not be deemed an admission that the reporting person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose. President and Chief Operating Officer /s/ Andrew Taylor, Attorney-in-Fact 2026-08-28